Journal article
Human papillomavirus 16-specific T-cell responses and spontaneous regression of anal high-grade squamous intraepithelial lesions
WWY Tong, K Shepherd, S Garland, A Meagher, DJ Templeton, CK Fairley, F Jin, I Mary Poynten, J Zaunders, RJ Hillman, AE Grulich, AD Kelleher, A Carr
Journal of Infectious Diseases | Published : 2015
Abstract
Background. Most anal cancers are attributable to persistent human papillomavirus type 16 (HPV-16) infection. The anal cancer precursor, high-grade squamous intraepithelial lesion (HSIL), frequently regresses spontaneously. We hypothesized that T-cell responses are associated with HSIL regression. Methods. In men who have sex with men undergoing anal cytology and high-resolution anoscopy, we measured responses to HPV-16 oncogenic proteins E6 and E7, using the CD25/CD134 assay for CD4+ antigen-specific T cells and intracellular cytokine staining for CD4+ and CD8+ antigen-specific T cells. Results. Of 134 participants (mean [SD] age, 51 [9.3] years; 31 [23.1%] infected with human immunodeficie..
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Awarded by National Health and Medical Research Council
Awarded by Cancer Council New South Wales Strategic Research Partnership
Funding Acknowledgements
This work was supported by the St Vincent's Clinic Foundation (annual grant 2011 and Di Boyd cancer grant 2013) and the Curran Foundation (annual grants 2012 and 2013). The SPANC study is funded by the National Health and Medical Research Council Program (grant 568971) and the Cancer Council New South Wales Strategic Research Partnership (grant SRP13-11).